Detectives are appealing for witnesses and information following a fail to stop collision in Stepney.
Police were called at around 01:18hrs on Friday, 21 April to reports of a collision between a car and a pedestrian in Commercial Road, near the junction with Belgrave Street, E1. The car did not stop at the scene.
Officers attended the collision along with London Ambulance Service and found a 39-year-old man injured at the scene.
He was taken to an east London hospital where he remains in a serious condition, described at potentially life changing but not life threatening.
Detectives from the Met's Roads and Transport Policing Command are investigating. They would like to speak with anyone who witnessed the collision or saw a black car speeding away from the area.
Anyone with information is asked to contact the Serious Collision Investigation Unit on 020 8597 4874 - alternatively call Crimestoppers anonymously on 0800 555 111.