Detectives are asking any witnesses or those with dash cam footage to come forward following a road traffic collision in Newham.
Police were called by the London Ambulance Service at 12:58hrs on Wednesday, 2 October to Temple Mills Lane, junction with Leyton Road, E15, after a truck was in a collision with a cyclist.
The cyclist, a woman aged in her 20s, was taken to an east London hospital. Her condition is not life-threatening but may be life-changing.
The driver of the truck stopped at the scene and was not arrested.
Road closures were in place but have since been re-opened.
Officers from the Serious Collision Investigation Unit ask anyone who can assist the investigation to call 020 8597 4847
Alternatively call 101 or tweet @MetCC ref CAD 3401/2 Oct.