Detectives are appealing for witnesses to a collision between a car and a cyclist in Tower Hamlets.
Police were called to Poplar High Street junction with Bazely Street E14 at 18:59hrs on Monday, 9 September following reports of a collision.
Officers and London Ambulance Service attended and found a car in collision with a male cyclist.
The cyclist, aged 17, was taken to hospital, initially in a critical condition. He injuries have now been assessed as life-changing.
The driver of the car, a maroon Ford Focus, involved in the collision fled the scene. Efforts to trace them continue.
No arrests have been made.
Detective Sergeant Lauren Brady, of Central East Command Unit, said: "This is being treated as a grievous bodily harm with intent investigation.
"We believe the victim was deliberately targeted and was dragged a significant distance underneath the vehicle.
"I know there were a number of witnesses and anyone who hasn't contacted police, or people with any dash-cam footage, are asked to call police via 101 quoting reference Cad 6546/09Sep. Alternatively, call Crimestoppers anonymously, on 0800 555 111."