Police were called at 09:35hrs this morning to a collision in Stamford Hill, N16.
A car reportedly mounted the pavement and struck a number of pedestrians.
Five people have been injured; one of those is believed to be in a life-threatening condition.
London Ambulance Service were in attendance and have since taken the injured persons to east London hospitals for treatment.
The incident is not being treated as terror-related.
Enquiries are ongoing; no arrests have been made.
Anyone with information, video or images that could assist police are asked to call 101 ref CAD/1782.